Table 3.

Association of coagulation parameters with Hb and anaemia at third trimester

Independent variables	Outcome variables
	Unadjusted coefficient (95% CI)	Adjusted* coefficient (95% CI)	P value—test for linear trend
	D-dimer (mg/dl)
Hb	0.96 (0.94 to 0.97)	0.96 (0.94 to 0.98)	<0.001
No/mild anaemia	1 (ref)†	1 (ref)†	0.003‡
Moderate anaemia	1.11 (1.02 to 1.20)	1.08 (0.99 to 1.17)
Severe anaemia	1.25 (1.04 to 1.50)	1.27 (1.07 to 1.50)
	Fibrinogen (mg/dl)
Hb	14.68 (11.11 to 18.24)	15.58 (12.08 to 19.09)	<0.001
No/mild anaemia	0 (Ref)	0 (Ref)	<0.001‡
Moderate anaemia	−40.5 (−55.3 to −25.7)	−39.2 (−53.7 to −24.9)
Severe anaemia	−111.1 (−143.4 to −78.9)	−117.2 (−148.3 to −86.1)
	D-dimer/fibrinogen ratio
Hb	0.92 (0.90 to 0.95)	0.93 (0.91 to 0.95)	<0.001
No/mild anaemia	1 (ref)†	1 (ref)†	<0.001‡
Moderate anaemia	1.21 (1.09 to 1.34)	1.17 (1.06 to 1.29)
Severe anaemia	1.63 (1.30 to 2.06)	1.69 (1.36 to 2.09)
	International normalised ratio
Hb	0.98 (0.97 to 0.99)	0.99 (0.98 to 0.99)	0.001
No/mild anaemia	1 (ref)†	1 (ref)†	0.007‡
Moderate anaemia	1.03 (0.99 to 1.06)	1.02 (0.98 to 1.05)
Severe anaemia	1.09 (1.02 to 1.17)	1.12 (1.04 to 1.19)
	Platelets (X 109/L)
Hb	−3.79 (−5.83 to −1.74)	−4.57 (−6.64 to −2.49)	NA
No/mild anaemia	−26.04 (−34.40 to −17.68)	−26.09 (−34.51 to −17.67)	NA
Moderate anaemia	0 (ref)	0 (ref)
Severe anaemia	−45.21 (−63.91 to −26.51)	−37.78 (−56.47 to −19.09)

*Adjusted for gestational age, maternal age, hypertensive disorders of pregnancy, pre-existing medical problems and hospital-code.

†Exponent of Log, hence reference is ‘1’ (instead of 0)

‡P value—test for linear trend.

Hb, haemoglobin; NA, not applicable.