Table 2A:
Odds ratio (OR)1 and p-value for association between SNP rs1910301 and risk of metastatic disease or prostate cancer death in three independent cohorts
| Cohort | OR for metastatic disease | P value |
|---|---|---|
| PHS/HPFS | 1.40 (1.05 – 1.84) | 0.02 |
| DFCI GC-EA | 1.35 (1.02 – 1.80) | 0.04 |
| FHCRC | 1.35 (0.97 – 1.85) | 0.07 |
| Meta-analysis of 3 cohorts [fixed effects model] | 1.37 (95% CI: 1.15–1.62) | 0.0003 |
PHS/HPFS: Physicians’ Health Study and Health Professionals Follow-up Study; DFCI GC: Dana-Farber Cancer Institute Gelb Center; EA: The ECOG-ACRIN Cancer Research Group; FHCRC: Fred Hutchinson Cancer Research Center.
1
OR modeled as ordinal for the minor allele