Table 4.
Unadjusted and adjusted predictors of age of diagnosis with coronary artery disease at Tehran Heart Center from 2005 to 2015
| Unit | Unadjusted (95% CI)a | P-value | Adjusted (95% CI)b | P-value | |
|---|---|---|---|---|---|
| Sex (n = 90,094) | Male (vs. female) | − 3.12 (− 3.27, − 2.97) | < 0.001 | − 0.89 (− 1.09, − 0.68) | < 0.001 |
| Body mass index (n = 65,320) | One SD (4.5 kg/m2) | − 1.07 (− 1.15, − 0.99) | < 0.001 | − 1.52 (− 1.60, − 1.43) | < 0.001 |
| Total Cholesterol (n = 81,363) | One SD (47.3 mg/dL) | − 0.78 (− 0.85, − 0.71) | < 0.001 | Excludedc | – |
| LDL Cholesterol (n = 79,458) | One SD (38.7 mg/dL) | − 0.64 (− 0.72, − 0.57) | < 0.001 | − 0.43 (− 0.52, − 0.35) | < 0.001 |
| HDL Cholesterol (n = 80,899) | One SD (10.6 mg/dL) | 1.39 (1.32, 1.47) | < 0.001 | 0.71 (0.62, 0.79) | < 0.001 |
| Triglycerides (n = 81,390) | One SD (96.9 mg/dL) | − 1.87 (− 1.94, − 1.80) | < 0.001 | − 1.35 (− 1.45, − 1.26) | < 0.001 |
| Dyslipidemia (n = 89,899) | Yes (vs. No) | − 1.65 (− 1.80, − 1.50) | < 0.001 | − 0.81 (− 1.00, − 0.62) | < 0.001 |
| Fasting blood sugar (n = 79,822) | One SD (53.3 mg/dL) | 0.12 (0.05, 0.19) | 0.002 | − 0.32 (− 0.42, − 0.22) | < 0.001 |
| Diabetes mellitus (n = 89,977) | Yes (vs. No) | 1.24 (1.10, 1.39) | < 0.001 | 1.05 (0.84, 1.26) | < 0.001 |
| Hypertension (n = 90,001) | Yes (vs. No) | 3.98 (3.84, 4.12) | < 0.001 | 3.54 (3.37, 3.71) | < 0.001 |
| Ever cigarette smoking (n = 89,955) | Yes (vs. No) | − 4.41 (− 4.55, − 4.26) | < 0.001 | − 2.76 (− 2.95, − 2.57) | < 0.001 |
| Ever opium use (n = 87,348) | Yes (vs. No) | − 4.22 (− 4.43, − 4.02) | < 0.001 | − 2.20 (− 2.44, − 1.96) | < 0.001 |
aAll differences are shown for age at diagnosis by unit in each predictor
bMutually adjusted for all other variables
cTotal cholesterol was not included in the model due to high collinearity with other variables