Table 3.
SNVs associated with cognitive ability and synaptic plasticity of glutamatergic neurons
| Gene | SNP | Cognitive abilities | Verbal reasoning | Numerical ability | Mechanical reasoning | Space relations | Abstract reasoning | Verbal comprehension | Grammar and language | Perceptual speed and accuracy |
|---|---|---|---|---|---|---|---|---|---|---|
| GRIN1 | rs4880213 |
F = 4.090 P = 0.018 |
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| GRIN2B | rs1805502 |
F = 3.827 P = 0.022 |
F = 2.948 P = 0.053 |
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| GRIN2C | rs3744215 |
F = 4.340 P = 0.013 |
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| GRIN3A | rs10989589 |
F = 4.081 P = 0.017 |
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| rs3739722 |
F = 3.420 P = 0.033 |
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| GRIN3B | rs2240154 |
F = 4.423 P = 0.012 |
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| rs4807399 |
F = 3.755 P = 0.024 |
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| rs2240157 |
F = 3.697 P = 0.025 |
F = 3.360 P = 0.035 |
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| rs2285906 |
F = 4.103 P = 0.017 |
F = 4.034 P = 0.018 |
F = 3.543 P = 0.030 |
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| rs10417824 |
F = 3.064 P = 0.047 |
F = 4.454 P = 0.012 |
F = 4.056 P = 0.018 |
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| rs10401454 |
F = 5.412 P = 0.005 |
F = 3.158 P = 0.043 |
F = 4.883 P = 0.008 |
F = 5.123 P = 0.006 |
F = 5.832 P = 0.003 |
F = 3.437 P = 0.033 |
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| GRIA1 | rs548294 |
F = 4.000 P = 0.019 |
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| CaMK2A | rs2241694 |
F = 3.248 P = 0.041 |
F, F ratio = Between estimate/within estimate = (SSB/dfb)/(SSW/dfw) SSB, Sum of squares between groups, SSW: Sum of squares within groups; dfb, Between groups degrees of freedom; dfw, Within groups degrees of freedom
P, p < 0.05