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. 2021 Oct 4;9(10):e002505. doi: 10.1136/jitc-2021-002505

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Local molecular changes in liver metastases at the end of monotherapy with NOX-A12 in the OPERA trial allows clustering of patients. (A) Unsupervised clustering of patients based on relative changes in the molecular immune landscape at the end of NOX-A12 monotherapy. In the heatmap, relative changes are expressed as Z-scores. (B) Concentrations of the most affected cytokines before and at the end of the monotherapy in patients clustered in tissue responders and tissue non-responders.CXCL10, chemokine (C-X-C motif) ligand 10; IL, interleukin; IFN, interferon; TNR, tissue non-responders; TR, tissue responders.