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. 2021 Oct 4;9(10):e002505. doi: 10.1136/jitc-2021-002505

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Comparative immune landscape in tissues at the onset of treatment with NOX-A12 and impact of NOX-A12 in the immune landscape in responders and non-responders. (A) Density of effector T cells in liver metastases split in three regions (LM=liver metastasis, IM=invasive margin and AL=adjacent liver) in tissue responders and non-responders. (B–D) Relative changes in T cell density in the regions depicted in (A) in the corresponding patients, expressed as (density(d14) – density(d0)*100/density(d0)), for CD3 (B), CD8 (C) and PD1 stains (D). (E) Distribution/proximity analysis of T cells in the tissue biopsy collected at the onset (left) and at the end (right) of the NOX-A12 monotherapy, in tissue responders and non-responders. (F) Modification in the T cell skewness in all biopsies. CXCL12, chemokine (C-X-C motif) ligand 12.