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. 2021 Oct 3;9(10):e003499. doi: 10.1136/jitc-2021-003499

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Phenotype analysis of TILs throughout expansion. (A) Single marker expression analysis of the unstimulated TILs before (unstimulated TILs), after initial in vitro expansion (young TILs) and after the REP TILs. Expression is shown as the fraction of CD3+ cells. (B) Comparison of CD103+ and CD8+CD103+TILs during the in vitro expansion according to disease control (partial response and/or stable disease >4.5 months). The difference was tested for significance with a non-parametric Mann-Whitney U test. CD4 expression is low in unstimulated TILs as the dissociation agent (collagenase IV) is known to cleave CD4. CM, central memory; EM, effector memory; EMRA, terminally differentiated effector memory; ns, not significant; REP, rapid expansion protocol; TIL, tumor-infiltrating lymphocyte.