Table 3.
Multivariable logistic regression testing for the effect of histological variant on cancer specific mortality (CSM) according to treatment protocol in the overall population.
| Histological variant | Overall | NAC+RC | RC+AC | RC only | RC+perioperative CHT |
|---|---|---|---|---|---|
| Adenocarcinoma | 0.91 (0.49–1.67) p=0.75 | 0.36 (0.08–1.65) p=0.19 | 5.20 (1.74–15.52) p=0.003 | 0.39 (0.10–1.58) p=0.19 | 1.03 (0.42–2.51) p=0.95 |
| Pure Adenocarcinoma | 0.66 (0.27–1.63) p=0.37 | 0.19 (0.02–1.56) p=0.12 | 9.28 (1.99–43.28) p=0.005 | 0.61 (0.15–2.48) p=0.49 | 0.95 (0.29–3.15) p=0.93 |
| UC with glandular component | 1.30 (0.57–2.94) p=0.53 | 1.95 (0.22–17.03) p=0.54 | 3.75 (0.85–16.56) p=0.08 | NA | 1.87 (0.57–6.15) p=0.31 |
| Micropapillary | 1.31 (0.84–2.04) p=0.24 | 1.24 (0.49–3.15) p=0.65 | 2.48 (1.11–5.56) p=0.03 | 1.02 (0.51–2.02) p=0.96 | 1.69 (0.90–3.15) p=0.10 |
| SCC | 1.36 (1.03–1.79) p=0.03 | 2.10 (1.07–4.15) p=0.03 | 2.36 (1.32–4.23) p=0.004 | 0.94 (0.62–1.42) p=0.77 | 1.95 (1.25–3.04) p=0.003 |
| Pure SCC | 0.98 (0.63–1.52) p=0.92 | 3.38 (1.19–9.59) p=0.02 | 3.27 (1.15–9.31) p=0.03 | 0.48 (0.25–0.95) p=0.03 | 3.36 (1.60–7.03) p=0.001 |
| UC and SCC component | 1.74 (1.22–2.46) p=0.002 | 1.61 (0.68–3.80) p=0.28 | 2.11 (1.06–4.17) p=0.03 | 1.73 (1.05–2.85) p=0.03 | 1.67 (0.98–2.82) p=0.06 |
| Small cell | 1.20 (0.65–2.21) p=0.55 | 2.50 (0.85–7.32) p=0.09 | NA | 1.13 (0.46–2.78) p=0.79 | 1.47 (0.57–3.81) p=0.43 |
| Pure Small-cells | 1.24 (0.58–2.66) p=0.57 | 3.00 (0.90–10.04) p=0.07 | 1.30 (0.32–5.31) p=0.71 | 1.40 (0.51–3.84) p=0.52 | |
| UC with small-cell component | 1.17 (0.43–3.16) p=0.76 | 2.03 (0.27–15.46) p=0.49 | 1.09 (0.34–3.47) p=0.89 | 2.02 (0.27–14.82) p= 0.49 |
|
| Sarcoma | 4.67 (2.79–7.82) p<0.0001 | 1.86 (0.23–14.89) p=0.56 | 21.72 (4.79–98.56) p=0.004 | 3.97 (2.11–7.48) p<0.0001 | 6.96 (2.41–20.13) p=0.0003 |
| Pure Sarcoma | 9.02 (3.98–20.91) p=<0.0001 | 4.84 (0.58–40.62) p=0.14 | 36.86 (3.01–452.64) p=0.005 | 7.88 (2.33–26.67) p=0.001 | 9.86 (2.16–45.01) p=0.003 |
| UC with sarcomatoid component | 3.66 (1.92–6.97) p=0.0001 | NA | 16.46 (2.45–110.56) p=0.004 | 3.48 (1.67–7.28) p=0.001 | 5.11 (1.16–22.39) p=0.03 |
| Other subtypes | 1.35 (0.84–2.17) p=0.21 | 1.23 (0.28–5.39) p=0.78 | 0.99 (0.39–2.56) p=0.99 | 1.79 (0.85–3.79) p=0.13 | 0.95 (0.41–2.19) p=0.90 |
***
adjusted for pTN stages + LND+ RT to primary tumor + surgical margins status + age at cystectomy + gender + smoke habits + CCI.
Abbreviations:
UC: Urothelial carcinoma
SCC: Squamous-cell carcinoma
RC: Radical cystectomy
NAC: Neoadjuvant chemotherapy
AC: Adjuvant chemotherapy
CHT: Chemotherapy