Fig. 1.

Treatment with indomethacin promoted e.c. papain Th2 and Th17 sensitization. The animal groups administered with indomethacin or vehicle were e.c. sensitized to papain (0.1, 1, or 10 mg/mL) via intact ear skin. a Time line. b Antibody responses. c Skin DLN cell cytokine responses restimulated in vitro. Data are indicated as the mean ± SD of 5 mice per group (b) and 3 wells of pooled DLN cells (c) and are representative of 3 independent experiments with similar results. c Detection limits are indicated by dotted lines. *p < 0.05 by the t test (b) or ANOVA (c: vs. no indomethacin, among the 8 groups). ^#p < 0.05 by ANOVA (b: vs. 0.1 mg/mL, among the 3 animal groups; c: vs. medium, among the 8 groups). DLN, draining lymph node; e.c., epicutaneous.