Fig. 2.

Treatment with indomethacin promoted allergic airway inflammation in mice, which were e.c. papain sensitized and subsequently i.n. challenged with low-dose papain. The animal groups administered with indomethacin or vehicle were e.c. sensitized (0.1, 1 or 10 mg/mL papain) via intact ear skin and subsequently i.n. challenged (2.5 μg papain). a Time line. b Airway inflammation. c Antibody responses. Data are indicated as the mean ± SD of 5 mice per group and are representative of 3 independent experiments with similar results. *p < 0.05 by the t test or Mann-Whitney U test (b, c). ^#p < 0.05 (vs. 0.1 mg/mL among the 3 animal groups) by ANOVA (b) and the Kruskal-Wallis test (c). ^$p < 0.05 by the t test or Mann-Whitney U test (c: vs. the Fig. 1b data obtained before i.n. challenge). e.c., epicutaneous. BAL, bronchial alveolar lavage