Fig. 5.

Co-treatment with COX-1-selective and COX-2-selective inhibitors promoted Th2/Th17 differentiation in e.c. papain sensitization. Mice were administered with COX-inhibitor(s) or vehicle during e.c. sensitization. All the animal groups were e.c. sensitized to 10 mg/mL papain via intact ear skin. a Time line. b Skin DLN cell cytokine responses restimulated in vitro. Data are indicated as the mean ± SD of 3 wells of pooled DLN cells from 3 or 4 mice and are representative of 3 independent experiments with similar results. Detection limits are indicated by dotted lines. *p < 0.05 by t test (vs. no inhibitors). COX-1 inhibitor, SC560. COX-2 inhibitor, rofecoxib. COX, cyclooxygenase; DLN, draining lymph node; e.c., epicutaneous.