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. Author manuscript; available in PMC: 2021 Oct 5.
Published in final edited form as: J Thromb Haemost. 2018 Apr 6;16(5):991–1002. doi: 10.1111/jth.13964

Fig. 2.

Fig. 2.

Cpb2−/− mice have worse liver and kidney damage in hemolytic-uremic syndrome (HUS) compared with wild-type (WT) mice. Disease was induced by treatment with Stx2 and lipopolysaccharide (LPS) together as described in Methods and mice were sacrificed at 48 h for blood collection (n = 10). (A) Platelet count, (B) blood urea nitrogen (BUN), (C) creatinine, (D) alanine transaminase (ALT) and (E) aspartate transaminase (AST). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. (F) Blood smear showing schistocytes (open arrows) in a sample from Cpb2−/− mice but not WT mice. (G) Kidney section harvested ante-mortem stained with H&E. Arrows point to necrotic tubular epithelial cells. The sections were examined under a Nikon 40×/0.95 objective lens using a Nikon Eclipse E1000M and images captured with a Diagnostic Instruments 15.2 Mp Shifting Pixel using Spot Imaging solutions Version 5.3 acquisition software.