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Anti-C5 antibody prolongs survival in the hemolytic-uremic syndrome (HUS) model in both Cpb2−/− and wild-type (WT) mice. Disease was induced by treatment with Stx2 and lipopolysaccharide (LPS) together as described in Methods and mice were followed until death (n = 11). Anti-C5 antibody was administered intraperitoneally at 3 h before disease induction and then every 24 h. Data were analyzed by the log rank method with the Bonferroni correction for multiple tests.
