TABLE 2.
Linear regression analysis of quantified tissue endothelial markers and laboratory parameters with plasma markers for volume and inflammation.
| Plasma markers of volume overload | Plasma markers of inflammation | |||
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| NT-proBNP (↑) | Sodium (↓) | CRP (↑) | Lymphocytes (↓) | |
| Tissue endothelial markers | ||||
| UEA1 (↓) | R = −0.50; P < 0.01 | R = 0.69; P < 0.001 | R = −0.44; P = 0.07 | R = 0.69; P = 0.002 |
| VEGFR2 (↑) | R = 0.29; P = 0.03 | R = −0.54; P < = 0.05 | R = 0.11; P = 0.24 | R = 0.34; P = 0.61 |
| vWF (↑) | R = 0.29; P = 0.03 | R = 0.28; P = 0.54 | R = 0.11; P = 0.90 | R = 0.26; P = 0.18 |
| Patient characteristics | ||||
| Age | R = −0.38; P = 0.16 | R = 0.11; P = 0.66 | R = 0.15; P = 0.56 | R = 0.04; P = 0.89 |
| BMI | R = 0.05; P = 0.86 | R = −0.36; P = 0.14 | R = −0.29; P = 0.26 | R = −0.39; P = 0.14 |
| Systolic blood pressure | R = 0.18; P = 0.53 | R = −0.17; P = 0.50 | R = −0.25; P = 0.33 | R = −0.47; P = 0.06 |
| Diastolic blood pressure | R = 0.20; P = 0.48 | R = 0.07; P = 0.79 | R = 0.10; P = 0.72 | R = 0.07; P = 0.80 |
| Laboratory parameters | ||||
| Serum creatinine | R = 0.68 P < 0.01 | R = −0.27 P = 0.27 | R = −0.25 P = 0.34 | R = −0.71 P < 0.01 |
| eGFR | R = −0.63 P = 0.02 | R = 0.09 P = 0.73 | R = −0.04 P = 0.99 | R = 0.58 P = 0.03 |
| Serum albumin | R = −0.15 P = 0.60 | R = 0.32 P = 0.20 | R = −0.16 P = 0.56 | R = −0.27 P = 0.33 |
| Urine creatinine | R = −0.68 P < 0.01 | R = −0.71 P = 0.27 | R = −0.25 P < 0.01 | R = −0.71 P < 0.01 |
| Proteinuria | R = 0.42 P = 0.16 | R = −0.71 P < 0.01 | R = −0.20 P = 0.50 | R = −0.70 P = 0.01 |
| Markers of volume overload | ||||
| Plasma NT-proBNP | – | R = −0.45; P = 0.04 | R = 0.56;P = 0.01 | R = −0.60; P < 0.01 |
| Plasma sodium | – | – | R = −0.33; P = 0.14 | R = 0.64; P < 0.01 |
| Tissue fluid content | R = 0.35 P = 0.17 | R = −0.06 P = 0.81 | R = 0.43 P = 0.07 | R = 0.07 P = 0.79 |
| Plasma markers of inflammation | ||||
| CRP | R = 0.56 P = 0.01 | R = −0.33 P = 0.14 | – | R = −0.19 P = 0.42 |
| Leukocytes | R = 0.13 P = 0.59 | R = 0.26 P = 0.22 | R = 0.26 P = 0.25 | R = 0.36 P = 0.12 |
| Monocytes | R = 0.05 P = 0.83 | R = 0.07 P = 0.78 | R = −0.13 P = 0.60 | R = 0.26 P = 0.27 |
| Lymphocytes | R = −0.61 P < 0.01 | R = 0.64 P < 0.01 | R = −0.19 P = 0.42 | – |
Arrows next to parameters indicate the direction of value change in CKD patients. Significant results are shown in bold italics.