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. 2019 Oct 31;43(2):zsz223. doi: 10.1093/sleep/zsz223

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© Sleep Research Society 2019. Published by Oxford University Press [on behalf of the Sleep Research Society].

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Effect of systemic injection of α-methylhistamine and thioperamide on motor activity in iron-deficient (ID) rats over 2-hour epochs recording. α-Methylhistamine failed to change periodic leg movement (PLM) in sleep (PLMS, left panel) at any time after injection. In contrast, thioperamide injection decreased PLMS in ID rats (left panel). Neither α-methylhistamine nor thioperamide changed PLM in quiet wake (right panel). Thirty percent dimethyl sulfoxide–saline (DMSO–saline) vehicle injection had no any effect on PLM in sleep (left panel) and in quiet wake (right panel). Data expressed as mean ± SD. Green bars and stars: baseline vs. thioperamide injection; black bars and stars: S/DMSO vs. thioperamide injection. H 2, H 4, H 6, and H8: hours 1–2, hours 3–4, hours 5–6, and hours 7–8 post-drug injection. *p < 0.05, **p < 0.01, ***p < 0.001, post hoc test. N = 7 each.