Skip to main content
. Author manuscript; available in PMC: 2021 Oct 5.
Published in final edited form as: Glia. 2020 Aug 3;69(1):91–108. doi: 10.1002/glia.23886

FIGURE 8.

FIGURE 8

Schwann cells (SCs) lacking integrins α5 and αV in vivo can remyelinate and regenerate the nerve after injury. (a) Adult Itgavf/f and Itgavf/f; P0-Cre sciatic nerves were crushed, then examined at 15 (T15) and 30 (T30) days postcrush. Shown are semithin cross sections of portion of nerve distal to the crush site. Remyelination and axon regeneration in αV cKO appeared similar to controls. Scale bars are 12.5 μm. (b) Nerve crush was repeated in Itga5f/f; Itgavf/f and Itga5f/f; Itgavf/f; P0-Cre adults. No morphological difference was detected between controls and α5/αV conditional double knockout (cdKO). Scale bars are 12.5 μm. (c,d) Average number of myelinated fibers per 140 cm2 area (field of view [fov]) in αV(c) and α5/αV (d) at T30. Differences were not statistically significant in both cohorts (student’s t test, n = 3 animals/genotype, ≥5 fields quantified per animal)