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Dosing strategy for aducanumab.9
| Protocols | ApoE ɛ4 carriers | ApoE ɛ4 non-carriers | ||
|---|---|---|---|---|
| Versions 1–3 | Low dose | High dose | Low dose | High dose |
| 3 mg/kg after titration over 8 weeks | 6 mg/kg after titration over 24 weeks | 6 mg/kg after titration over 24 weeks | 10 mg/kg after titration over 24 weeks | |
| Versions 4–6 | 3 mg/kg after titration over 8 weeks | 10 mg/kg after titration over 24 weeks | 6 mg/kg after titration over 24 weeks | 10 mg/kg after titration over 24 weeks |
