Table 11.

Pharmacokinetic parameters of 8 compounds after oral administration of TWMM (n = 6).

Compounds	Tmax (h)	Cmax (ng/mL)	t1/2 (h)	AUC (0–36) (h·ng/mL)	AUC (0–∞) (h·ng/mL)	MRT (0–36) (h)	MRT (0–∞) (h)
Oleuropein	1.37 ± 1.60	0.90 ± 0.82	3.36 ± 0.00	1.03 ± 0.75	1.03 ± 0.75	1.53 ± 1.25	1.54 ± 1.25
Chlorogenic acid	0.39 ± 0.32	16.13 ± 4.17	2.71 ± 0.11	33.95 ± 4.55	33.95 ± 4.55	4.97 ± 0.71	4.97 ± 0.71
Formononetin	0.46 ± 0.29	6.17 ± 1.65	11.70 ± 2.09	40.78 ± 8.51	45.96 ± 7.89	10.69 ± 1.17	15.73 ± 1.90
Verbascoside	0.25 ± 0.14	45.47 ± 21.16	2.08 ± 0.38	174.81 ± 40.83	174.81 ± 40.83	8.90 ± 3.44	8.91 ± 3.44
Linarin	0.16 ± 0.10	12.78 ± 8.82	2.81 ± 0.21	12.04 ± 4.72	12.04 ± 4.72	4.26 ± 2.67	4.26 ± 2.68
Luteolin	1.71 ± 1.79	3.27 ± 0.78	11.14 ± 10.20	38.46 ± 7.61	43.98 ± 4.19	11.36 ± 1.23	18.20 ± 9.14
Jaspolyside	0.38 ± 0.31	14.25 ± 3.67	29.15 ± 12.65	46.59 ± 9.58	53.37 ± 32.17	11.42 ± 1.29	15.62 ± 10.83
Specnuezhenide	0.46 ± 0.29	13.33 ± 4.61	20.27 ± 25.00	48.62 ± 19.41	57.19 ± 30.25	11.02 ± 5.63	19.29 ± 16.60