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Levels of independent variable in the central composite design
| Factor | Level | ||||
|---|---|---|---|---|---|
| −α | −1 | 0 | +1 | +α | |
| X1 | 1.38 | 2 | 3.5 | 5 | 5.62 |
| X2 | 25.86 | 30 | 40 | 50 | 54.14 |
X1 (the ratio of emulsifier to co-emulsifier) and X2 (percentage of oil, %); Y1 (drug loading, mg/mL) and Y2 (particle size, nm)
