Table IV.

Analysis of variance (ANOVA) of the model parameters

	Source	Sum of Squares	df	F value	P value	Significance
Drug loading (Y1)	Model	551.3	5	10.73	0.0035	**
	A-A	23.49	1	2.29	0.1743
	B-B	366.5	1	35.66	0.0006	**
	AB	30.69	1	2.99	0.1276
	A2	28.67	1	2.79	0.1388
	B2	114.68	1	11.16	0.0124	*
	Residual	71.94	7
	Lack of Fit	26.94	3	0.8	0.5558
	Pure Error	45	4
	Cor Total	623.24	12
Particle size (Y2)	Model	2904.74	5	123.29	< 0.0001	**
	A-A	76.24	1	16.18	0.005	**
	B-B	2595.43	1	550.81	< 0.0001	**
	AB	12.18	1	2.58	0.1519
	A2	64.38	1	13.66	0.0077	**
	B2	180.91	1	38.39	0.0004	**
	Residual	32.98	7
	Lack of Fit	3.98	3	0.18	0.9027
	Pure Error	29	4
	Cor Total	2937.72	12

**Extremely significantly (P<0.01); *significant (P<0.05)