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. 2021 Sep 21;12:687563. doi: 10.3389/fphys.2021.687563

FIGURE 4.

FIGURE 4

VE-cadherin regulates collecting lymphatic vessel solute permeability (Ps). Collecting lymphatic vessels were perfused with either isotype control antibody (IgG) or a VE-cadherin function blocking antibody (clone: BV13, 100 μg/mL). (A) Ps to 3 kDa dextran in the presence of IgG antibody (black bars) or following treatment with BV13 antibody (red bars) (n = 5). (B) Ps to BSA in the presence of IgG (black bars) or following treatment with BV13 (red bars) (n = 5). (C) Collecting lymphatic vessels perfused with IgG or BV13 (100 μg/ml) were fixed and stained for DAPI (blue) and VE-cadherin (red). All graphs show mean ± SD and each “n” refers to a different mouse. *, P < 0.05 by two-way ANOVA. Scale bar is 20 μm.