Fig 3. CD11c⁺ and Lyz2⁺ cells contribute to PGE₂ production in vivo.

Indicated strains of mice were infected with 10⁷ LADD L. monocytogenes. 12hpi spleens were harvested and assessed for PGE₂ by mass spectrometry. Data was normalized to d-PGE₂ levels and percent change is compared to L. monocytogenes-infected controls (A). Indicated strains of mice were infected with 10⁷ LADD L. monocytogenes. 7dpi splenocytes were examined for B8R-specific CD8⁺ T-cell responses. %IFNγ (B) or number IFNγ (C) per spleen was assessed. Data shown are representative of two independent experiments. Significance was determined by a one-way ANOVA with Bonferroni’s correction (A). *p < 0.05, **p < 0.01, ***p < 0.001.