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. 2021 Sep 21;12:733577. doi: 10.3389/fphar.2021.733577

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Copyright © 2021 Caputi, Carboni, Rullo, Alessandrini, Balzani, Melotti, Romualdi, Candeletti and Fanelli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Global DNA methylation levels in patients at different time-points. (A): Plot of the least square predicted means with 95% confidence intervals. The predicted least square means were calculated using a 1-way repeated measures mixed model. *p < 0.05; ***p < 0.001 in planned comparisons with T0 levels. (B): variation in methylation levels between time-points. The percentage of patients showing increased (Incr. Meth.) or decreased (Decr. Meth.) methylation levels with respect to the previous time-point is shown. (C): DNA methylation levels in each patient at every time-point. n = 11 patients repeatedly assessed at 5 time-points.