TABLE 3.

Correlation analysis between DNA methylation and DNMT and cytokine expression. Significant p values are displayed in bold. 0.05 < p< 0.1 values are displayed in italics.

Categorisation factor	First variable		Second variable	n	Correlation coefficient	Test statistic	p-value
T0	DNMT1a	vs.	DNMT3a	11	0.373	1.205	0.259
T0	DNMT1a	vs.	DNMT3b	11	0.262	0.814	0.4365
T0	DNMT1a	vs.	IL6	11	−0.272	−0.849	0.4179
T0	DNMT1a	vs.	percent meth.	11	0.549	1.972	0.08
T0	DNMT1a	vs.	TNFα	11	−0.333	−1.058	0.3175
T0	DNMT3a	vs.	DNMT3b	11	0.393	1.284	0.2312
T0	DNMT3a	vs.	IL6	11	0.191	0.585	0.5732
T0	DNMT3a	vs.	percent meth.	11	0.591	2.2	0.0553
T0	DNMT3a	vs.	TNFα	11	0.082	0.246	0.8109
T0	DNMT3b	vs.	IL6	11	−0.314	−0.991	0.3477
T0	DNMT3b	vs.	percent meth.	11	0.358	1.149	0.2804
T0	DNMT3b	vs.	TNFα	11	−0.441	−1.474	0.1745
T0	IL6	vs.	percent meth.	11	−0.066	−0.2	0.8462
T0	IL6	vs.	TNFα	11	0.986	17.536	<0.0001
T0	percent meth.	vs.	TNFα	11	−0.144	−0.437	0.6722
T1	DNMT1a	vs.	DNMT3a	11	0.331	1.052	0.3201
T1	DNMT1a	vs.	DNMT3b	11	0.603	2.266	0.0496
T1	DNMT1a	vs.	IL6	11	0.062	0.185	0.8571
T1	DNMT1a	vs.	percent meth.	11	0.164	0.5	0.629
T1	DNMT1a	vs.	TNFα	11	−0.054	−0.163	0.874
T1	DNMT3a	vs.	DNMT3b	11	−0.252	−0.783	0.4539
T1	DNMT3a	vs.	IL6	11	0.654	2.593	0.0291
T1	DNMT3a	vs.	percent meth.	11	0.005	0.014	0.9888
T1	DNMT3a	vs.	TNFα	11	0.449	1.508	0.1659
T1	DNMT3b	vs.	IL6	11	−0.651	−2.571	0.0302
T1	DNMT3b	vs.	percent meth.	11	−0.013	−0.039	0.97
T1	DNMT3b	vs.	TNFα	11	−0.63	−2.431	0.0379
T1	IL6	vs.	percent meth.	11	−0.172	−0.524	0.6131
T1	IL6	vs.	TNFα	11	0.85	4.847	0.0009
T1	percent meth.	vs.	TNFα	11	0.145	0.439	0.6708
T2	DNMT1a	vs.	DNMT3a	11	0.26	0.807	0.4403
T2	DNMT1a	vs.	DNMT3b	11	0.864	5.15	0.0006
T2	DNMT1a	vs.	IL6	11	−0.633	−2.454	0.0365
T2	DNMT1a	vs.	percent meth.	11	0.093	0.281	0.7852
T2	DNMT1a	vs.	TNFα	11	−0.625	−2.401	0.0398
T2	DNMT3a	vs.	DNMT3b	11	0.539	1.921	0.0869
T2	DNMT3a	vs.	IL6	11	−0.176	−0.535	0.6055
T2	DNMT3a	vs.	percent meth.	11	0.075	0.225	0.827
T2	DNMT3a	vs.	TNFα	11	−0.383	−1.243	0.2453
T2	DNMT3b	vs.	IL6	11	−0.759	−3.498	0.0067
T2	DNMT3b	vs.	percent meth.	11	0.325	1.03	0.3298
T2	DNMT3b	vs.	TNFα	11	−0.776	−3.694	0.005
T2	IL6	vs.	percent meth.	11	−0.391	−1.275	0.2341
T2	IL6	vs.	TNFα	11	0.861	5.075	0.0007
T2	percent meth.	vs.	TNFα	11	−0.5	−1.733	0.1171
T3	DNMT1a	vs.	DNMT3a	11	0.005	0.014	0.9891
T3	DNMT1a	vs.	DNMT3b	11	0.535	1.9	0.0898
T3	DNMT1a	vs.	IL6	11	0.114	0.345	0.7377
T3	DNMT1a	vs.	percent meth.	11	−0.38	−1.234	0.2484
T3	DNMT1a	vs.	TNFα	11	−0.033	−0.099	0.9234
T3	DNMT3a	vs.	DNMT3b	11	0.696	2.91	0.0173
T3	DNMT3a	vs.	IL6	11	0.605	2.28	0.0486
T3	DNMT3a	vs.	percent meth.	11	−0.226	−0.695	0.5047
T3	DNMT3a	vs.	TNFα	11	0.419	1.383	0.2
T3	DNMT3b	vs.	IL6	11	0.296	0.928	0.3776
T3	DNMT3b	vs.	percent meth.	11	−0.346	−1.105	0.2978
T3	DNMT3b	vs.	TNFα	11	0.135	0.407	0.6933
T3	IL6	vs.	percent meth.	11	−0.745	−3.349	0.0085
T3	IL6	vs.	TNFα	11	0.925	7.283	<0.0001
T3	percent meth.	vs.	TNFα	11	−0.772	−3.64	0.0054
T4	DNMT1a	vs.	DNMT3a	11	0.004	0.011	0.9912
T4	DNMT1a	vs.	DNMT3b	11	0.369	1.191	0.2642
T4	DNMT1a	vs.	IL6	11	−0.22	−0.677	0.5153
T4	DNMT1a	vs.	percent meth.	11	−0.353	−1.133	0.2865
T4	DNMT1a	vs.	TNFα	11	−0.249	−0.772	0.4597
T4	DNMT3a	vs.	DNMT3b	11	0.656	2.61	0.0283
T4	DNMT3a	vs.	IL6	11	0.347	1.109	0.296
T4	DNMT3a	vs.	percent meth.	11	0.191	0.582	0.5746
T4	DNMT3a	vs.	TNFα	11	0.114	0.344	0.7389
T4	DNMT3b	vs.	IL6	11	0.107	0.324	0.7533
T4	DNMT3b	vs.	percent meth.	11	0.168	0.511	0.6218
T4	DNMT3b	vs.	TNFα	11	−0.017	−0.051	0.9605
T4	IL6	vs.	percent meth.	11	−0.085	−0.257	0.8031
T4	IL6	vs.	TNFα	11	0.954	9.514	<0.0001
T4	percent meth.	vs.	TNFα	11	−0.131	−0.395	0.7017