Fig. 8.

Substantial AKS-452-induced immunogenicity in an NHP (cynomolgus monkeys) in the absence of adjuvant. Animals received three doses of either 100 µg or 1,000 µg AKS-452 without adjuvant at 21 days apart. Serum was collected at designated times and evaluated for (A) anti-SP/RBD IgG Ab titers by ELISA (using an NHP serum reference curve reported as Reference Unit Titer values) and (B) SARS-CoV-2 anti-nucleocapsid, anti-whole SP Ag, anti-viral lysate, and anti-SP/RBD via Luminex immunoassay (reported as raw MFI values).