TABLE 5.
MICs of seven antimicrobial agents for the M. fortuitum group reported by four laboratories
| Drug | MIC (μg/ml) for isolatea:
|
|||||||
|---|---|---|---|---|---|---|---|---|
| 1351
|
1352
|
1353
|
1359
|
|||||
| Mode (range) | % Agreement | Mode (range) | % Agreement | Mode (range) | % Agreement | Mode (range) | % Agreement | |
| Amikacin | 2 (1–4) | 100 | 1 (1–2) | 100 | 1 (1–2) | 100 | 1 (1) | 100 |
| Cefoxitin | 32 (16–64) | 100 | 64 (16–128) | 97.2 | 16 (2–32) | 97.2 | 16 (2–32) | 91.7 |
| Ciprofloxacin | 0.125 (0.125–0.25) | 100 | 0.125 (0.125–0.5) | 97.2 | 0.125 (0.125–0.25) | 100 | 1 (0.5–2) | 100 |
| Clarithromycin | 64 (0.25–128) | 27.8 | 4 (1–128) | 61.1 | 0.25 (0.03–2) | 72.2 | 0.25 (0.03–0.5) | 88.9 |
| Doxycycline | 64 (4–64) | 97.2 | 64 (16–64) | 97.2 | 0.25 (0.25–1) | 97.2 | 0.25 (0.25–1) | 97.2 |
| Imipenem | 4 (1–16) | 66.7 | 4 (1–32) | 58.3 | 8 (1–32) | 75.0 | 8 (1–8) | 66.7 |
| Sulfamethoxazole | 2 (1–16) | 77.8 | 1 (1–128) | 41.7 | 1 (1–64) | 86.1 | −b (1–128) | 55.5 |
a
% Agreement, percentage of MICs in each three-dilution range (mode ± log2). High off-scale MICs were converted to the next-highest concentration; low off-scale MICs were left unchanged.
b
No modal MIC (agreement is the three-dilution range encompassing largest number of MICs).