Table 1.

Hotspots found by analyzing the positional entropy. To determine a hotspot region a running mean (window length = 15, step size = 1) is calculated and top 100 value are selected. We found six such regions of interest in our analysis in which ten mutations of interest emerged.

Hotspots	Mutation
211–225	A222V
439–453	N439K, L452R, Y453F
473–487	S477 N, T478K, E484K
487–501	N501Y
602–616	D614G
1121–1135	V1122L