Figure 1.
Flow chart of the multimodal canonical correlation analysis with reference plus joint independent component analysis fusion pipeline. The preprocessed MRI features (ie, ReHo from resting-state fMRI, GMV from T1-weighted, and FA from DWI) are entered with global cognitive scores as the reference. After completing the cognition-guided fusion, component loadings and spatial maps for each modality are generated. Abbreviations: DWI, diffusion-weighted imaging; FA, fractional anisotropy; GMV, gray matter volume; HIV, human immunodeficiency virus; Mics, M independent components; MRI, magnetic resonance imaging; Ref, reference; rs-fMRI, resting-state functional magnetic resonance imaging; ReHo, regional homogeneity.