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Competitive substitution model between H1 and ProTα. Histone linker H1 (red) is predominantly positively charged, while its nuclear chaperone ProTα (blue) is predominantly negatively charged. The proteins interact via electrostatics to form a binary complex. A second ProTα chain may attach to a region of H1 within the binary complex, forming a transient ternary complex, and compete with the initial ProTα chain for electrostatic interaction with H1.
