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. 2021 Oct 6;11(10):210033. doi: 10.1098/rsob.210033

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© 2021 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 3. — Graphs generated by the DepMap portal showing the cell growth effect of CRISPR mediated ablation of ZDHHC20 or ZDHHC5 in Kras-mutant lung cancer cell lines plotted against the mRNA expression of an EGFR ligand EGF. (a) The negative cell growth with ZDHHC20 CRISPR correlates with EGF expression only in Kras-mutant cell lines suggesting a correlation with EGFR activation (p-value = 0.02, Pearson = −0.5). (b) This correlation is not observed with ZDHHC5 CRISPR (p-value = 0.9, Pearson = −0.01).