Table 3.
Multivariable Analysis of Risk Factors at Study Enrollment Associated With the Incident Burden of Non-AIDS Comorbidities in Women Living With or at Risk for Human Immunodeficiency Virus Infection
| Risk Factor | Estimated Incident NACM Rate (95% CI) | IRR (95% CI) | P Valuea |
|---|---|---|---|
| HIV serostatusb | |||
| Positive | 0.21 (.20–.22) | 1.36 (1.02–1.81) | <.0001 |
| Negative | 0.17 (.16–.18) | Ref | |
| Age group, yb | |||
| ≥55 | 0.22 (.19–.26) | 1.71 (1.41–2.09) | <.0001 |
| 50–54 | 0.23 (.21–.26) | 1.66 (1.38–2.00) | |
| 45–49 | 0.23 (.21–.26) | 1.72 (1.47–2.02) | |
| 40–44 | 0.22 (.20–.24) | 1.46 (1.25–1.70) | |
| 35–39 | 0.20 (.18–.21) | 1.36 (1.17–1.58) | |
| 30–34 | 0.17 (.15–.18) | 1.21 (1.04–1.41) | |
| 25–29 | 0.14 (.13–.16) | 1.06 (.90–1.25) | |
| <25 | 0.13 (.11–.14) | Ref | |
| BMI, kg/m2 | |||
| ≥30 | 0.20 (.19–.22) | 1.15 (1.09–1.21) | <.0001 |
| <30 | 0.18 (.16–.19) | Ref | |
| Race | |||
| Non-Hispanic black | 0.17 (.16–.18) | 0.83 (.78–.89) | <.0001 |
| Hispanic | 0.19 (.17–.20) | 0.89 (.83–.97) | |
| Other non-Hispanic | 0.19 (.16–.22) | 0.91 (.78–1.05) | |
| White | 0.21 (.19–.22) | Ref | |
| Education | |||
| High school or less | 0.19 (.18–.20) | 1.01 (.96–1.07) | .6504 |
| More than high school | 0.19 (.17–.20) | Ref | |
| Income | |||
| <$12 000 | 0.20 (.19–.22) | 1.12 (1.05–1.20) | .0002 |
| $12 001–$24 000 | 0.18 (.17–.20) | 1.02 (.95–1.10) | |
| >$24 000 | 0.18 (.17–.19) | Ref | |
| Marital status | |||
| Had a partner | 0.19 (.18–.20) | 1.01 (.96–1.08) | .1680 |
| Never partner/other | 0.18 (.17–.20) | 0.96 (.91–1.01) | |
| Married/partner | 0.19 (.17–.20) | Ref | |
| Own residence | |||
| No | 0.20 (.18–.21) | 1.08 (1.02–1.14) | .0067 |
| Yes | 0.18 (.17–.19) | Ref | |
| Cigarette use | |||
| Current | 0.21 (.19–.22) | 1.19 (1.12–1.27) | <.0001 |
| Former | 0.19 (.17–.20) | 1.09 (1.02–1.17) | |
| Never | 0.17 (.16–.19) | Ref | |
| Current alcohol use | |||
| >7 drinks/wk | 0.19 (.17–.20) | 0.96 (.88–1.04) | .1457 |
| 1–7 drinks/wk | 0.18 (.17–.20) | 0.95 (.90–1.00) | |
| None | 0.19 (.18–.21) | Ref | |
| Crack/cocaine use | |||
| Current | 0.20 (.18–.21) | 1.10 (1.02–1.19) | .0310 |
| Former | 0.19 (.17–.21) | 1.06 (.99–1.14) | |
| Never | 0.18 (.17–.19) | Ref |
Abbreviations: BMI, body mass index; CI, confidence interval; HIV, human immunodeficiency virus; IRR, incidence rate ratio; NACM, non-AIDS comorbidity; Ref, reference value.
aAdjusted linear regression with all covariates listed included in the model plus Women’s Interagency HIV Study enrollment wave and HIV × age interaction (P = .0438 for the interaction term).
bAdjusted for HIV serostatus × age interaction.