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. 2020 Dec 16;73(7):e2387–e2396. doi: 10.1093/cid/ciaa1647

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© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Plasma biomarkers of hypoxia in cerebral malaria (CM). Levels of microRNA 150 (miRNA-150; A) and lipocalin-2 (B) were measured in the plasma of all patients and plotted according to age and disease category. C, Both miRNA-150 and lipocalin-2 were plotted against plasma levels of Plasmodium falciparum histidine-rich protein 2 and grouped according to age. Statistical significance was obtained from Mann-Whitney U test (A and B) and Spearman correlation analysis (C). *P < .05; **P < .005; ***P < .0005. Abbreviations: CM, cerebral malaria; PfHRP2, Plasmodium falciparum histidine-rich protein 2; RELs, relative expression levels; UM, uncomplicated malaria.