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. 2021 Oct 5;2021:2911578. doi: 10.1155/2021/2911578

Figure 2.

Figure 2

Overview of effects of SARS-CoV-2 infection on the muscle and bone. The SARS-CoV-2 infection elicits systemic inflammation (Cytokine storm), which activates the tryptophan-kynurenine pathway. Kynurenine is broken down into several downstream metabolites, which further activates AhR signaling, affecting the integrity and structure of the musculoskeletal system. (Figure is created by using http://BioRinder.com.)