Table 2.
Association between Hcy and incident of the first IS in different models.
| Exposure | Crude model (HR to 95% CI to P) | Adjust model I (HR to 95% CI to P) | Adjust model II (HR to 95% CI to P) | Adjust model III (HR to 95% CI to P) |
|---|---|---|---|---|
| Continuous | ||||
| Hcy (per SD increment) | 1.37 (1.30 to 1.44) <0.01 | 1.35 (1.27 to 1.42) <0.01 | 1.34 (1.26 to 1.43) <0.01 | 1.32 (1.24 to 1.38) <0.01 |
| Categorical | ||||
| Hcy tertiles (μmol/L) | ||||
| Tertile 1 (<11.6) | Reference | Reference | Reference | Reference |
| Tertile 2 (11.6–18.2) | 2.91 (2.42 to 3.49) <0.01 | 2.67 (2.22 to 3.20) <0.01 | 2.33 (1.94 to 2.72) <0.01 | 2.13 (1.74 to 2.59) <0.01 |
| Tertile 3 (>18.2) | 2.75 (2.29 to 3.31) <0.01 | 2.23 (1.85 to 2.70) <0.01 | 1.96 (1.73 to 2.19) <0.01 | 1.76 (1.43 to 2.17) <0.01 |
Crude model: adjusted for none. Adjust model I: adjusted for age and gender at baseline. Adjust model II: adjusted for variables in adjusted model I plus smoking status, drinking status, NC, WC, and BMI at baseline. Adjust model III: fully adjusted model. Adjusted for variables in adjusted model II plus SBP, DBP, history of arrhythmia and diabetes, AHI, AI, HI, sleep duration, mean SaO2 and lowest SaO2, antidiabetic drugs, antiplatelet drugs, lipid-lowering drugs, regular CPAP treatment, antihypertensive drugs, and TC, TG, HDL-c, LDL-c, FPG, eGFR, Cr, and hs-CRP levels at baseline. Abbreviations are the same as in Table 1.