Table 4.
Association between Hcy and the first IS in various subgroups.
| Stratification variable | No. of participants. | HR (95% CI) | 95% CI low | 95% CI high | P value | P for interaction |
|---|---|---|---|---|---|---|
| Gender | 0.63 | |||||
| Female | 744 | 1.20 | 0.65 | 2.22 | 0.56 | |
| Male | 1606 | 1.40 | 1.13 | 1.74 | <0.01 | |
| Diabetes | 0.51 | |||||
| No | 1937 | 1.39 | 1.12 | 1.73 | <0.01 | |
| Yes | 413 | 1.16 | 0.70 | 1.92 | 0.57 | |
| Arrhythmia | 0.18 | |||||
| No | 2306 | 1.24 | 1.05 | 1.46 | 0.01 | |
| Yes | 440 | 1.41 | 1.27 | 1.57 | <0.01 | |
| Smoking status | 0.63 | |||||
| Never | 1342 | 1.33 | 0.94 | 1.88 | 0.10 | |
| Former | 258 | 1.78 | 1.04 | 3.05 | 0.04 | |
| Current | 750 | 1.34 | 0.99 | 1.80 | 0.05 | |
| Drinking status | 0.65 | |||||
| Never | 1557 | 1.43 | 1.12 | 1.82 | <0.01 | |
| Former | 166 | 1.24 | 0.63 | 2.46 | 0.54 | |
| Current | 627 | 1.13 | 0.72 | 1.79 | 0.59 | |
| Age (years) | 0.87 | |||||
| <60 | 1911 | 1.36 | 1.07 | 1.73 | 0.01 | |
| ≥60 | 439 | 1.42 | 0.96 | 2.08 | 0.08 | |
| BMI (kg/m2) | 0.03 | |||||
| <24 | 221 | 1.13 | 0.95 | 1.33 | 0.16 | |
| ≥24, <28 | 934 | 1.46 | 1.26 | 1.70 | <0.01 | |
| ≥28 | 1195 | 1.46 | 1.25 | 1.70 | <0.01 | |
| SBP (mmHg) | 0.41 | |||||
| <140 | 1084 | 1.25 | 0.86 | 1.82 | 0.23 | |
| ≥140 | 1266 | 1.51 | 1.18 | 1.92 | <0.01 | |
| DBP (mmHg) | 0.04 | |||||
| <90 | 887 | 1.20 | 1.02 | 1.42 | 0.03 | |
| ≥90 | 1463 | 1.48 | 1.33 | 1.65 | <0.01 | |
| AHI (events/hour) | 0.37 | |||||
| ≥5, <15 | 934 | 1.46 | 1.04 | 2.07 | 0.03 | |
| ≥15, <30 | 722 | 1.47 | 1.04 | 2.09 | 0.03 | |
| ≥30 | 694 | 1.07 | 0.73 | 1.56 | 0.74 | |
| FPG (mmol/L) | 0.72 | |||||
| <6.1 | 1991 | 1.38 | 1.23 | 1.54 | <0.01 | |
| ≥6.1 | 359 | 1.32 | 1.04 | 1.66 | 0.02 | |
| eGFR (mL/min/1.73 m2) | 0.59 | |||||
| <90 | 941 | 1.42 | 1.08 | 1.85 | 0.01 | |
| ≥90 | 1409 | 1.27 | 0.93 | 1.72 | 0.13 |
Note 1: adjusted for age, gender, smoking status, drinking status, NC, WC, BMI, SBP, DBP, history of arrhythmia, diabetes, AHI, AI, HI, sleep duration, mean SaO2 and lowest SaO2, antidiabetic drugs, antiplatelet drugs, lipid-lowering drugs, regular CPAP treatment, antihypertensive drugs, and TC, TG, HDL-c, LDL-c, FPG, eGFR, Cr, and hs-CRP levels at baseline. Note 2: in each case, the model was not adjusted for hierarchical covariates. Abbreviations are the same as in Table 1.