Figure 5. TCR signaling–dependent pancreatic T cell tissue residency is lost upon CoRT-induced Foxo1/S1PR1.

(A and B) BDC and (C) BDC.S1pr1-GFP mice were treated with ND αCD4 or control Ab (n = 6), immunized 6 hours later with sBDC, and after 18 hours pancreatic CD4⁺ T cells were examined by FACS. Error bars depict SD. *P < 0.05, **P < 0.01, ***P < 0.001, determined by 2-way ANOVA (A–C). Data are pooled from 2–3 experiments.