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. 2021 Sep 8;6(17):e138088. doi: 10.1172/jci.insight.138088

Figure 9. Elevated mRNA levels of selected genes in SN of MP and human PD.

Figure 9

(A) ChIP-qPCR validation of higher enrichment of H3K27ac at multiple gene promoters using littermate controls (LCs) and MP mice (n = 4). (B) RT-qPCR of selected genes from integrated RNA-Seq and ChIP-Seq data in SN of LC and MP mice and (C) postmortem SN from age-matched human control and PD subjects with n = 3 (2 technical replicates). Bar graphs show mean ± SEM of unpaired 2-tailed Student t tests. NS, not significant; *P ≤ 0.05; **P < 0.01.