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. 2021 Sep 8;6(17):e147472. doi: 10.1172/jci.insight.147472

Figure 3. Circulating levels of HA and hyaluronidase activity correlate with clinical and inflammatory signatures of COVID-19.

Figure 3

(A–D) Correlation analysis severity of sequential organ failure assessment (SOFA) scores with plasma HA concentration and hyaluronidase activity levels in COVID-19 (n = 46) (A and C) and sepsis (n = 23) (B and D) patients. (E) Spearman correlation matrix of plasma HA, hyaluronidase (HA’ase) activity, and cytokines in patients with COVID-19 (n = 46) demonstrated to be statistically significant (*P < 0.05) between healthy controls and patients with COVID-19. Yellow indicates a positive correlation, and purple indicates a negative correlation. Pearson correlation coefficient was used to determine the r value of the correlation between the 2 groups.