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. 2021 Sep 8;6(17):e147472. doi: 10.1172/jci.insight.147472

Figure 5. Circulating HA is present as pathological low–molecular weight fragments.

Figure 5

The molecular weight profile of HA was fractionated stepwise and measured by competitive ELISA assay. (A and B) HA from patient plasma (A) or pulmonary microvascular endothelial cells stimulated with either healthy donor or COVID-19 patient plasmas (B) is reported as the relative abundance of LMW-HA fragments (<50 kDa, n = 5 patients each). (C) ELISA measurement of HA-HC in plasma from patients with COVID-19 (n = 46) or healthy donors (n = 18). A thick dashed line indicates the median, and thin dashed lines indicate either quartile. Data are reported as mean ± SEM; ***P < 0.001, using unpaired Student’s t test, 2 tailed.