Figure 5. PERK deletion in POMC neurons abrogates the celastrol-induced increase in systemic leptin sensitivity.

(A and B) Twenty-four hour food intake (A) and twenty-four hour food intake normalized with body weight (B) after leptin (i.p., 5 mg/kg) or PBS injection with/without 2-day pretreatment with celastrol (i.p., 100 μg/kg; n = 6–12, per group). Data are from male mice and are expressed as mean ± SEM. Three-way repeated measures ANOVA with Sidak’s post hoc analyses, *P < 0.05; **P < 0.01.