Skip to main content
. 2021 Sep 22;6(18):e150405. doi: 10.1172/jci.insight.150405

Figure 7. Downregulation of Sprr1a in mice reduces cardiac stress and fibrosis after MI.

Figure 7

(A) Representative H&E staining of heart sections of periischemic border area at 8 weeks after MI shows a decrease in disorganized structure, as well as in loss of normal architecture and cellular integrity in Sprr1ahypo/hypo hearts compared with WT controls. Scale bars: 100 μm. (B and C) Representative Masson’s trichrome staining in heart sections of periischemic border area at 8 weeks after MI (B) and fibrosis quantification in LVs (C). Scale bars: 100 μm. One-way ANOVA with Tukey multiple-comparison test. ***P < 0.001 versus sham; ###P < 0.001 versus MI WT. Data are presented as mean ± SEM.