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. 2021 Sep 22;6(18):e150862. doi: 10.1172/jci.insight.150862

Figure 6. Therapeutic blockade of IL-8 signaling attenuates ARDS-related microthrombosis in vivo.

Figure 6

(A) Illustration of in vivo SARS-CoV-2 S1 spike protein–induced lung injury mouse model. (B) Clinical sepsis score at 24 hours after S1 spike protein–induced lung injury for control and reparixin-treated hACE2 mice. (C) Quantification and representative micrographs of fibrinogen-positive/fibrinogen-binding neutrophils in one vessel in the lungs of control or reparixin-treated mice. Scale bar: 10 μm. (D) Quantification and representative micrographs of microthrombi in lungs of vehicle or reparixin-treated mice. Vessel borders are shown with dashed white lines. Scale bar: 50 μm. (B–D) Two-tailed unpaired Student’s t test, n = 4 per group. Data are shown as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.