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. 2021 Sep 8;6(17):e143472. doi: 10.1172/jci.insight.143472

Figure 8. SERCA and STIM1 are displaced in the longitudinal SR at the Z-line.

Figure 8

(A) Confocal micrographs of double immunolabeling for STIM1 (green, left) and SERCA1 (red, middle) was performed in (A) WT (top panel) and (B) DES-KO fibers (bottom panel). (C) Overlap of STIM1 (r = 0.225) and SERCA (r = 0.226) (P = 0.99) were quantified and compared based on the Pearson’s coefficient for WT (n = 3 mice, 14 fibers) and DES-KO fibers (n = 3 mice, 16 fibers). Results indicate overlap between STIM1 and SERCA. (D) Quantitative Western blotting for sarcolipin (SLN) was done for protein lysates from WT (n = 5 animals) and DES-KO (n = 5 animals) muscle. Magnification, ×63. *P < 0.05.