Figure 8. Citrate provides photoreceptor resilience against death and prolongs function long-term in adRP.

(A) Representative ERG traces for adRP mice (black) and adRP mice treated with citrate (blue) at a 2.5 log cd•s/m² flash intensity. (B) Quantification of the a-wave and (C) b-wave amplitudes over time. (D) Representative ERG traces at a –1.1 log cd•s/m² flash intensity. (E) Quantification of the b-wave amplitudes over time. (F) Photopic ERG traces for WT mice (purple) and untreated and citrate-treated adRP mice at a 3.1 log cd•s/m² flash intensity. (G) Quantification of the peak amplitudes. n ≥ 7 eyes. Statistical analysis by 1-way ANOVA (G) or multiple 2-tailed t tests with the Holm-Sidak correction (B, C, and E). Data are represented as mean ± SEM. *P < 0.05. adRP, autosomal dominant retinitis pigmentosa; ERG, electroretinogram