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. 2021 Sep 8;6(17):e150203. doi: 10.1172/jci.insight.150203

Figure 7. Epigenetic heterogeneity and dynamics.

Figure 7

(A) Distribution of global CpG methylation levels across gene bodies in tumor and normal samples. TSS, transcription start site; TES, transcription end site. (B) The coefficient of variation was calculated to assess intertumor DNA methylation heterogeneity per patient. (C) Epiallele shifts per million loci (EPM) in each sample. (D) Two patterns depict the dynamics of methylation level under treatments. Pattern 1 assumed that hypomethylation level of promoter regions facilitated MDR and tumorigenesis, and pattern 2 assumed that hypermethylation promoted the evolutionary processes of MDR. (E) Lollipop plot shows the CpG methylation level of SLC7A8 promoter region for each patient. (F) Altered pathway (protein digestion and absorption) composed of mutant SLC7A8 and promoter hypomethylation of SLC8A3. KEGG, Kyoto Encyclopedia of Genes and Genomes.