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. 2021 Sep 8;6(17):e147057. doi: 10.1172/jci.insight.147057

Figure 7. A model of CD36-mediated outside-in and inside-out LCFA transport.

Figure 7

Postprandially, insulin signaling activates extracellular LCFA uptake mediated by acylated CD36 at the cell surface in complex with PHB and ANX2. Deacylation of CD36 enables caveolar endocytosis and lipid droplet trafficking of LCFA-bound CD36. In lipolytic conditions, CD36 deacylation, caveolar endocytosis, and lipid droplet trafficking enable CD36 loading with LCFA released from lipid droplets and their plasma membrane trafficking and release via exocytosis.