Table 3.
Paired Neurologic, Neuropsychological, Mood, and CSF Immune Activation Marker Data Across ATI
| CNS Measure | Sample | Pre-ATI | During ATI | Post-ATI | P Value |
|---|---|---|---|---|---|
| % with any neurologic findings | n = 28 | 25% | – | 18% | P = .515 |
| Median no. neurologic findings (IQR, range) | n = 28 | 0 (0–0.75; 0–7) | – | 0 (0–0.75; 0–5) | P = .305 |
| Median composite NPZ-global (96.9% CI) | n = 18 | 0.95 (.33–1.30) | – | 1.13 (.61–1.52) | *P < .001 |
| Median Color Trails 1 z score (96.9% CI) | n = 18 | 1.47 (.64–1.73) | – | 1.54 (1.16–2.01) | *P = .040 |
| Median Color Trails 2 z score (96.9% CI) | n = 18 | 1.06 (.57–1.25) | – | 1.20 (.90–1.62) | *P = .007 |
| Median Grooved Pegboard z score (96.9% CI) | n = 18 | 0.71 (.41–1.10) | – | 0.86 (.23–1.23) | P = .064 |
| Median Trails A z score (96.9% CI) | n = 18 | 1.45 (.73–1.80) | – | 1.36 (1.01–1.75) | P = .890 |
| Flanker computed score (97.9% CI) | n = 16 | 8.87 (8.27–9.30) | 8.96 (8.44–9.56) | 9.14 (8.36–9.59) | P = .143 |
| Flanker average response time (97.9% CI) | n = 10 | 0.76 (.56–.94) | 0.75 (.60–.88) | 0.78 (.55–.88) | P = –657 |
| Median PHQ-9 depression score (98.7% CI) | n = 14 | 3.5 (0–8) | – | 5.0 (2–7) | P = .510 |
| Median HADS depression score (98.7% CI) | n = 14 | 1.0 (0–3) | – | 1.5 (0–6) | P > .999 |
| Median HADS anxiety score (98.7% CI) | n = 14 | 3.0 (2–7) | – | 3.0 (2–9) | P = .677 |
| Median distress thermometer rating (98.7% CI) | n = 14 | 1.5 (.5–4.0) | – | 2.5 (1.5–6.3) | P = .252 |
| CSF neopterin pg/mL (99.2% CI) | n = 8 | 527 (332–1284) | 504 (221–909) | – | P > .999 |
| CSF CCL2/MCP-1 pg/mL (99.2% CI) | n = 8 | 690 (448–1024) | 644 (431–1281) | – | P = .461 |
| CSF CXCL10/IP-10 pg/mL (99.2% CI) | n = 8 | 428 (170–2220) | 361 (216–709) | – | P = .742 |
| CSF CD163 pg/mL (99.2% CI) | n = 8 | 5991 (5286–9851) | 6238 (5264–6939) | – | P = .945 |
| CSF s100B pg/mL (99.2% CI) | n = 8 | 1137 (887–1998) | 1214 (896–2357) | – | P = .078 |
Unless otherwise described, data are presented as median values with approximate 95% confidence interval (CI) of the median.
Abbreviations: ATI, analytic treatment interruption; CNS, central nervous system; CSF, cerebrospinal fluid; HADS, Hospital Anxiety and Depression Scale; IQR, interquartile range; NPZ-global, composite neuropsychological test z score; PHQ-9, Patient Health Questionnaire.