Table 3.
First principal components of metabolic pathways that differentiate HPV-associated HNSCC from smoking-associated HNSCC and their association with overall patient mortality via Cox models
| HR | CI | P value | |
|---|---|---|---|
| Bile acid biosynthesis 1 st PC | |||
| Unadjusted model | 0.52 | (0.38, 0.72) | <0.001 |
| HPV, smoking, age, sex adjusted model | 0.52 | (0.36, 0.76) | <0.001 |
| Fully adjusted modela | 0.58 | (0.37, 0.92) | 0.02 |
| Fully adjusted model among oropharyngeal tumor subjectsa | 0.45 | (0.17, 1.17) | 0.10 |
| Fully adjusted model among non-oropharyngeal subjectsa | 0.50 | (0.27, 0.94) | 0.03 |
| Galactose 1 st PC | |||
| Unadjusted model | 1.72 | (1.09, 2.72) | 0.02 |
| HPV, smoking, age, sex adjusted model | 1.28 | (0.79, 2.10) | 0.32 |
| Fully adjusted modela | 1.21 | (0.71, 2.08) | 0.48 |
| Fully adjusted model among oropharyngeal tumor subjectsa | 1.85 | (0.53, 6.49) | 0.34 |
| Fully adjusted model among non-oropharyngeal subjectsa | 1.04 | (0.60, 1.80) | 0.89 |
| Octadecatrienoic acid beta oxidation 1 st PC | |||
| Unadjusted model | 0.54 | (0.38, 0.78) | <0.001 |
| HPV, smoking, age, sex adjusted model | 0.65 | (0.44, 0.97) | 0.03 |
| Fully adjusted modela | 0.75 | (0.51, 1.10) | 0.14 |
| Fully adjusted model among oropharyngeal tumor subjectsa | 0.29 | (0.08, 1.02) | 0.05 |
| Fully adjusted model among non-oropharyngeal subjectsa | 0.74 | (0.47, 1.16) | 0.19 |
| Vitamin B6 1 st PC | |||
| Unadjusted model | 1.26 | (0.86, 1.86) | 0.23 |
| HPV, smoking, age, sex adjusted model | 0.93 | (0.61, 1.41) | 0.74 |
| Fully adjusted modela | 1.13 | (0.75, 1.72) | 0.56 |
| Fully adjusted model among oropharyngeal tumor subjectsa | 0.51 | (0.17, 1.53) | 0.23 |
| Fully adjusted model among non-oropharyngeal subjectsa | 1.35 | (0.84, 2.18) | 0.22 |
HR=Cox hazard ratio, CI=confidence interval, HPV=human papillomavirus, PC=principal component
a
adjusted for HPV and smoking status, age at study entry, sex, race, tumor stage, and patient ECOG status