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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2021 Jul 16;30(10):1816–1825. doi: 10.1158/1055-9965.EPI-21-0120

Table 4.

Hazard ratiosa and 95% CIs for the joint associations between WCRF/AICR lifestyle scores before and after colorectal cancer diagnosis and mortality.

Pre-diagnostic WCRF/AICR lifestyle scoreb P-interaction
Low score High score
Post-diagnostic WCRF/AICR lifestyle score with BMI c
Colorectal cancer specific mortality
   No. of events 76 18
   Low score referent 0.98 (0.60-1.59) 0.24
   No. of events 20 65
   High score 1.00 (0.64-1.59) 0.85 (0.60-1.22)
Overall mortality
   No. of events 266 68
   Low score referent 0.79 (0.60-1.02) 0.07
   No. of events 82 225
   High score 0.94 (0.74-1.20) 0.73 (0.60-0.88)
Post-diagnostic WCRF/AICR lifestyle score without BMI d
Colorectal cancer specific mortality
   No. of events 71 37
   Low score referent 1.12 (0.75-1.67) 0.82
   No. of events 25 46
   High score 0.68 (0.43-1.10) 0.62 (0.42-0.91)
Overall mortality
   No. of events 240 116
   Low score referent 0.86 (0.69-1.08) 0.19
   No. of events 108 177
   High score 0.75 (0.59-0.95) 0.59 (0.48-0.73)
a

Cox models were stratified by age at diagnosis (<65, ≥65 years) and tumor stage (I, II, III, and unspecified), with additional adjustment for age at diagnosis (continuous), cohort (NHS, HPFS), tumor grade (well differentiated, moderately differentiated, poorly differentiated, and unspecified), tumor subsite (proximal colon, distal colon, rectum, and unspecified), year of diagnosis (continuous), regular sigmoidoscopy/colonoscopy screening (yes, no), post-diagnostic total energy intake (continuous), post-diagnostic regular use of aspirin (yes, no), and post-diagnostic smoking status (current, non-current).

b

The cutpoint for the pre-diagnostic WCRF/AICR lifestyle score categories was 1.75 in NHS and 1.86 in HPFS.

c

The cutpoint for the post-diagnostic WCRF/AICR lifestyle score with BMI categories was 1.68 in NHS and 1.89 in HPFS.

d

The cutpoint for the post-diagnostic WCRF/AICR lifestyle score without BMI categories was 1.11 in NHS and 1.25 in HPFS.