Table 4.
Pre-diagnostic WCRF/AICR lifestyle scoreb | P-interaction | ||
---|---|---|---|
Low score | High score | ||
Post-diagnostic WCRF/AICR lifestyle score with BMI c | |||
Colorectal cancer specific mortality | |||
No. of events | 76 | 18 | |
Low score | referent | 0.98 (0.60-1.59) | 0.24 |
No. of events | 20 | 65 | |
High score | 1.00 (0.64-1.59) | 0.85 (0.60-1.22) | |
Overall mortality | |||
No. of events | 266 | 68 | |
Low score | referent | 0.79 (0.60-1.02) | 0.07 |
No. of events | 82 | 225 | |
High score | 0.94 (0.74-1.20) | 0.73 (0.60-0.88) | |
Post-diagnostic WCRF/AICR lifestyle score without BMI d | |||
Colorectal cancer specific mortality | |||
No. of events | 71 | 37 | |
Low score | referent | 1.12 (0.75-1.67) | 0.82 |
No. of events | 25 | 46 | |
High score | 0.68 (0.43-1.10) | 0.62 (0.42-0.91) | |
Overall mortality | |||
No. of events | 240 | 116 | |
Low score | referent | 0.86 (0.69-1.08) | 0.19 |
No. of events | 108 | 177 | |
High score | 0.75 (0.59-0.95) | 0.59 (0.48-0.73) |
Cox models were stratified by age at diagnosis (<65, ≥65 years) and tumor stage (I, II, III, and unspecified), with additional adjustment for age at diagnosis (continuous), cohort (NHS, HPFS), tumor grade (well differentiated, moderately differentiated, poorly differentiated, and unspecified), tumor subsite (proximal colon, distal colon, rectum, and unspecified), year of diagnosis (continuous), regular sigmoidoscopy/colonoscopy screening (yes, no), post-diagnostic total energy intake (continuous), post-diagnostic regular use of aspirin (yes, no), and post-diagnostic smoking status (current, non-current).
The cutpoint for the pre-diagnostic WCRF/AICR lifestyle score categories was 1.75 in NHS and 1.86 in HPFS.
The cutpoint for the post-diagnostic WCRF/AICR lifestyle score with BMI categories was 1.68 in NHS and 1.89 in HPFS.
The cutpoint for the post-diagnostic WCRF/AICR lifestyle score without BMI categories was 1.11 in NHS and 1.25 in HPFS.