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. Author manuscript; available in PMC: 2022 Oct 15.
Published in final edited form as: J Immunol. 2021 Sep 20;207(8):2005–2014. doi: 10.4049/jimmunol.2100225

Figure 1. Frequency of IgG isotype-specific VN-Glyc sites in the B cell receptor repertoire.

Figure 1.

Analysis of adaptive immune receptor repertoire sequencing showing the number of N-linked glycosylation motifs in AChR and MuSK MG BCR repertoires relative to HDs. (A) The number of N-linked glycosylation motifs (N-X-S/T) per VH gene segment sequence in the repertoire derived from healthy controls, AChR and MuSK MG patients. (B) The number of N-linked glycosylation motifs (N-X-S/T) per germline reverted VH gene segment sequence in the BCR repertoire derived from healthy controls, AChR and MuSK MG patients. A significance threshold of p <0.05 was used and shown on plots with a single asterisk. Arrows point to AChR MG-1 or MuSK MG-1 depending on the boxplot in (A) and (B).